Interesting Reasoning

In the Titanium chapter Levi shares a story of a girl and painter and how “In short, he did so many strange and new things that it was very interesting to stay there and watch him: and when the closet was white, he picked up the pot and many newspapers that were on the floor and carried everything next to the cupboard and began to paint that too. The closet was so shiny, clean, and white that it was almost indispensable to touch it”. Since Primo Levi’s work focuses on everyday life it is interesting to read about how he in a way resonated with Maria and her desire to touch the untouchable and new objects in her life. The diction used in the chapter of Titanium also shows how he was experiencing thigs for the first time and his admiration throughout the inconceivable wonders in his strange life. In the article by Professor Cohens A Bioinorganic Approach to Fragment-Based Drug Discovery Targeting Metalloenzymes he discusses how “Any medicinal chemist would view such an arbitrary and restrictive design criterion as nonsensical with respect to the available chemical space. By analogy, the bioinorganic chemist should view the singular use of the hydroxamic acid MBP as similarly unreasonable.” In this section I pulled from Professor Cohen he discusses how restrictive designs can lead to unreasonable findings and in way he was tying the chemicals with real world situations of how limiting oneself can lead to senseless findings and ultimately limit the sciences that follows into real life settings.  My question is then how would one know that it is time to take the unconventional path and want to try something that has never been tried or something unreasonable without direction?